Girl 6 was the first and only single to be released from the soundtrack album Girl 6 (a compilation of music by Prince and associated artists for the movie Girl 6, directed by Spike Lee), credited to The New Power Generation.
It was released in the USA, United Kingdom, and Japan a week after the album's release (many of the songs included on the soundtrack had been previously-released as singles, however).
The b-side, Nasty Girl by Vanity 6, was also included on the soundtrack album. The UK single also contained Erotic City by Prince and the Revolution, also included on the soundtrack album.
The single did not enter the US Billboard Hot 100 Chart, but reached number 78 on the Billboard R&B Chart.