Sister Fate was the first single to be released from Sheila E.’s second album Romance 1600, released four weeks before the album. The single contained an edit (removing an instrumental coda), an extended version, and an instrumental version of the track. The 12" single included a previously-unreleased track, Save The People, which contained no input by Prince. The single was released in North America and Germany.
The single did not enter the US Billboard Pop Chart, but reached number 36 on the Billboard Black Chart.
Prince appeared in the Sister Fate video promoting the single, although his appearance was taken directly from the Raspberry Beret video, and did not contain any new footage.